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      BD FACSLyric™ Clinical Flow Cytometry System

      Discover how this flow cytometer can transform your clinical lab with outstanding performance, automation and standardization

      Features Performance Applications Testimonials Resources Journal Publication

      Discover the BD FACSLyric™ Flow Cytometry System difference.

      • Witness clinical performance results through high sensitivity and improved resolution
      • Streamline your lab workflow through flexibility and automation, enabling efficiency and productivity
      • Achieve automated standardization through highly reproducible results and enable collaboration through assay portability
      • See how the BD FACSLyric™ System can transform your lab.

       

      Get more information from the BD FACSLyric™ Flow Cytometry System Brochure.

       
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      Features

      Discover the BD FACSLyric™ Flow Cytometry System—A Next-Generation Flow Cytometer

      Built on a foundation of excellence, experience and expertise, the BD FACSLyric™ Flow Cytometry System is a new standard for cell analysis, transforming the way your lab does flow cytometry. As with all BD instruments, the BD FACSLyric™ Flow Cytometry System is backed by 40 years of BD expert training, service and support—so there’s no limit to your potential.

       

      The Power of the BD FACSLyric™ Flow Cytometer

       

      • 4-, 6-, 8-, 10- and 12-color configurations. Onsite upgradeable to adapt to your lab's changing needs
      • Up to 3 lasers—blue, red and violet—12 fluorescence channels and 14 parameters
      • 35,000 events per second maximum acquisition rate; no limit on number of events acquired
      • Automated single-tube QC with BD® CS&T Beads
      • Fluorescence compensation required only every 60 days, improving efficiency and productivity
      • 21 different loading options: plates or tubes; built-in flexibility with BD FACS™ Universal Loader
      • Powered by the BD FACSuite™ Acquisition and Analysis Application, whose password protection, audit trail, electronic signatures and IQ/OQ procedures assist in supporting U.S, FDA 21 CFR Part 11 compliance
      • BD FACSLink™ Laboratory Information System (LIS) Interface and BD Assurity Linc™ Remote Systems Management Software streamline your workflow and help improve productivity through seamless integration.

       

      See how you can simplify your workflow using the automated instrument setup and compensation on the BD FACSLyric™ System.

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      Performance

      A new diagnostic standard delivering outstanding performance and standardization within and between instruments

      The BD FACSLyric™ Flow Cytometry System is a high-performance, highly sensitive flow cytometer that demonstrates exceptional resolution and improved separation to make dim and rare cell populations easier to resolve.

      BD FACSLyric™ and BD FACSCanto™ datatables.
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      Higher sensitivity makes dim and rare populations easier to resolve.

      Graph of BD FACSLyric™ and BD FACSCanto™ II performance.
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      Improvement in stain index of 8–190% across all parameters ensures better separation and enables faster analysis and easier gating.

      CD23 PE, Lambda PE, CD5 BV421 datatables.
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      Assay portability simplifies and standardizes instrument setup within your lab and between labs. It also enables the sharing and exchange of data, ideas, and IVD and user-defined protocols within and between institutions.

       

       

       

      Highly reproducible results between instruments drive standardization.

       

      BD FACSLyric™ System Variance (CVs)
      15 BD FACSLyric™ Systems: Lyse/Wash settings and BD FC® Beads
      Blue Laser %CV
      FITC 4.2
      PE 4.4
      PE-Cy7 4.8
      PerCP 10.2
      PerCP-Cy5.5 7.9
      Red Laser %CV
      APC 5.3
      APC-Cy7 4.1
      APC-H7 3.9
      APC-R700 4.2
         
      Violet Laser %CV
      BD Horizon™ V450 11.1
      BD Horizon™ V500 11
      BD Horizon™ BV605 13.6
      BD Horizon™ BV711 7.5
      BD Horizon™ BV786 15.3

       

      Between-instrument reproducibility of target MFI values on the BD FACSLyric™ System

      Lyse/wash assay settings were imported across 15 instruments to show effects of standardization on beads. The CVs of the fluorescence intensity across all channels varies by less than 15.3%. Daily QC with one lot of BD® Cytometer Setup & Tracking Beads was run on fifteen BD FACSLyric™ Flow Cytometers. For each instrument, the PMTV gains were automatically adjusted to meet the target values. BD® FC Beads acquired on each BD FACSLyric™ Instrument. The MFI of positive populations was measured for all parameters across all instruments. The %CV is shown. The data for this internal study were acquired using BD® FC Beads across 15 BD FACSLyric™ Instruments. Greater between-instrument variability could be observed when running biological samples, when using non BD reagents or when comparing fewer instruments. 

      Applications

      A Powerful Solution for CD4 Counts and Other Immunological Assessment

      With the BD FACSLyric™ Flow Cytometer, clinical laboratories can obtain repeatable and reliable results for immunological assessment of patients having or suspected of having an immune deficiency such as HIV.

      The BD FACSLyric™ Flow Cytometry System delivers improved clinical performance and accuracy in diagnosis with increased process efficiency and standardization.

      • BD Multitest™ Reagents, formulated to be used with BD Trucount™ Tubes, provide absolute counting capability.

      • The BD FACSuite™ Clinical Application, with predefined templates for 4- and 6-color T, B and/or NK cell analysis, provides reproducible and consistent results. 

      • Each reagent includes a cocktail of multiple fluorescently labeled monoclonal antibodies, premixed at the appropriate titer to ensure quality staining.

      A streamlined methodology for immunological assessment of patients having or suspected of having an immune deficiency such as HIV using the BD FACSLyric™ Flow Cytometer.

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      "BD is positioned with BD® CS&T and BD® FC Bead technology to enable instrument standardization simply from day to day, instrument to instrument, and lab to lab."

      Portrait of Dr. Wang for product testimonial.

      "BD is positioned with BD® CS&T and BD® FC Bead technology to enable instrument standardization simply from day to day, instrument to instrument, and lab to lab."

      Dr. Lili Wang
      NIST
      Gaithersburg, MD

      “The consistency and the regulatory compliance of FACSLyric [Flow Cytometer]’s output is what really drew us to the platform. It is currently unmatched by other flow cytometers in its ability to generate reliable, repeatable results across tests and instruments—even for the most complex assays we deal with day to day. We’ve found it particularly beneficial for multiparameter testing for CAR T cells and immunophenotyping.”

      Portrait of Dr Kromminga for product testimonial.

      “The consistency and the regulatory compliance of FACSLyric [Flow Cytometer]’s output is what really drew us to the platform. It is currently unmatched by other flow cytometers in its ability to generate reliable, repeatable results across tests and instruments—even for the most complex assays we deal with day to day. We’ve found it particularly beneficial for multiparameter testing for CAR T cells and immunophenotyping.”

      Dr. Arno Kromminga
      Chief Scientific Officer, BioAgilytix
      Europe

      “The assay portability of BD FACSLyric is the key to efficient method transfer and high data reproducibility. It represents a clear advantage in a regulated environment, where conditions must be met to produce valid results of a guaranteed level of quality. Functional immune cell–based assays and cytokine quantification in preclinical and clinical drug development is a particularly important area where BD FACSLyric offers clear technical advantages.”

      Portrait of Dr Moser for product testimonial.

      “The assay portability of BD FACSLyric is the key to efficient method transfer and high data reproducibility. It represents a clear advantage in a regulated environment, where conditions must be met to produce valid results of a guaranteed level of quality. Functional immune cell–based assays and cytokine quantification in preclinical and clinical drug development is a particularly important area where BD FACSLyric offers clear technical advantages.”

      Dr. René Moser
      Chief Executive Officer & Chief Scientific Officer, IBR Inc.
      Switzerland

      “The BD FACSLyric is a system for everyday work that every technician can use.”

      Portrait of Dr Hoffmann for product testimonial.

      “The BD FACSLyric is a system for everyday work that every technician can use.”

      Dr. Dennis Hoffman
      Labor Wisplinghoff
      Cologne, Germany
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      Resources
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      Journal Publication

      Omana-Zapata I, Mutschmann C, Schmitz J, et al. Accurate and reproducible enumeration of T-, B- and NK lymphocytes using the BD FACSLyric 10-Color System: a multisite clinical evaluation. PLoS One. 2019;14(1):e0211207. doi: 10.1371/journal.pone.0211207. 

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      BD FACSLyric™ Flow Cytometers are Class 1 Laser Products.

      The BD FACSLyric™ Flow Cytometer is For Research Use Only. Not for use in diagnostic or therapeutic procedures.

      The BD FACSLyric™ Flow Cytometer is for In Vitro Diagnostic Use with BD FACSuite™ Clinical Application for up to six colors. The BD FACSLyric™ Flow Cytometer is for Research Use Only with BD FACSuite™ Application for up to 12 colors. Not for use in diagnostic or therapeutic procedures.

      Cy is a trademark of Global Life Sciences Solutions Germany GmbH or an affiliate doing business as Cytiva.

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