Skip to main content Skip to navigation
Blood cancer constitutes a variety of hematologic malignancies involving white blood cells (WBCs), red blood cells (RBCs) and platelets. With advances in genetic and molecular technologies and the ability to characterize various types of immunological markers, our understanding of blood cancers has undergone tremendous progress.

What causes blood cancers?

Most blood cancers involve disruptions of the hematopoietic and immune systems. During the transformation of normal cells into cancerous cells (oncogenic process), both the common myeloid and common lymphoid progenitor populations arising from hematopoietic stem cells (HSCs) undergo uncontrolled proliferation. Based on the population affected, different types of blood cancers have been identified.

performance1

The three major types of blood cancers

Leukemia, lymphoma (Hodgkin and non-Hodgkin) and myeloma are the three major categories of blood cancer, but based on their phenotypes, several other subcategories have been identified.

Leukemia
down arrow up arrow

Leukemia[GY1]  arises due to an overproduction of WBCs. Based on the starting cell in the bone marrow, leukemia can be lymphocytic or myeloid. Lymphocytic leukemia arises from lymphocyte progenitors whereas non-lymphocytic or myeloid leukemia arises from progenitors of erythrocytes, granulocytes, monocytes or platelets. Based on the maturation of leukemic cells, leukemia is categorized into two types: acute or chronic.1,2 The prevalence of the disease varies based on age, stage and the type of leukemia (myeloid vs lymphoid).

References

1.      Malouf C, Ottersbach K. Molecular processes involved in B cell acute lymphoblastic leukaemia. Cell Mol Life Sci. 2018;75(3):417-446. doi:10.1007/s00018-017-2620-z

2.      Jiang M, Bennani MN, Feldman AL. Lymphoma classification update: T-cell lymphomas, Hodgkin lymphomas and histiocytic/dendritic cell neoplasms. Expert Rev Hematol. 2017;10(3):239-249. doi: 10.1080/17474086.2017.1281122

3.      Küppers R, Hansmann ML. The Hodgkin and Reed/Sternberg cell. Int J Biochem Cell Biol. 2005;37(3):511-517. doi:10.1016/j.biocel.2003.10.025

4.      Zeng Q, Schwarz H. The role of trogocytosis in immune surveillance of Hodgkin lymphoma. Oncoimmunology. 2020;9(1):1781334. doi:10.1080/2162402X.2020.1781334

5.      Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-2390. doi:10.1182/blood-2016-01-643569

 

BD flow cytometers are Class 1 Laser Products. 

BD Biosciences clinical flow cytometry solutions, including instrumentation, software and reagents, offer the building blocks for laboratory-developed tests used in the identification of markers associated with cancers. These solutions are not FDA cleared or approved for the diagnosis of cancers. Analyte Specific Reagent. Analytical and performance characteristics are not established.

23-23021-00

Log a Bug
Log a Bug