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Elevating Panel Design Possibilities with ASRs Conjugated to Two Additional BD Horizon Brilliant™ Dyes
BD continues to offer a portfolio of analyte specific reagents (ASRs), including the most number of violet laser dyes that are available conjugated to ASRs. Now available BD Horizon Brilliant Violet™ 711 (BV711) and BD Horizon Brilliant Violet™ 786 (BV786) ASRs further expand your laboratory’s options in multicolor panel design. BD Horizon™ BV711 and BV786 ASRs can be used on flow cytometers equipped with a violet laser (405 nm) and appropriate filters, such as the 12-color BD FACSLyric™ Flow Cytometer.
Clinical Brilliance Elevated
Illustrative examples from product development are shown in Figures 1, 2 and 3 which presents little variation in results from lot-to-lot of our BD Horizon Brilliant Violet™ ASRs.
![CD3 BV786 Graph](/content/dam/bdb/campaigns/elevated/cd3-bv786-graph.jpg)
Lot-to-lot consistency for CD3 BV786 ASR development lots 1 (orange) and 2 (blue). Lysed whole blood gated on lymphocytes.
![CD4 BV711 Graph](/content/dam/bdb/campaigns/elevated/cd4-bv711-1-graph.jpg)
Lot-to-lot consistency for CD4 BV711 ASR development lots 1 (orange) and 2 (blue). Lysed whole blood gated on lymphocytes.
![CD13 BV711 Graph](/content/dam/bdb/campaigns/elevated/cd13-bv711-graph.jpg)
Lot-to-lot consistency for CD13 BV711 ASR development lots 1 (orange) and 2 (blue). Unstained sample in black. Lysed whole blood gated on monocytes.
The BD Horizon™ BV711 and BV786 ASRs are typically as bright or brighter than our analogous research use only (RUO) reagents, helping you to resolve dim populations.
Illustrative examples from product development are shown in Figures 4, 5 and 6.
![CD38 BV711 Graph](/content/dam/bdb/campaigns/elevated/cd38-bv711-graph.jpg)
CD38 BV711 ASR (orange) compared to analogous CD38 BV711 RUO reagent (blue) [P/N: 740830]. Unstained sample in black. The CD38 BV711 ASR development lots are on average 45% brighter based upon positive population MFI. Lysed whole blood gated on monocytes.
![CD5 BV786 Graph](/content/dam/bdb/campaigns/elevated/cd5-bv786-graph.jpg)
CD5 BV786 ASR (orange) compared to analogous CD5 BV786 RUO reagent (blue) [P/N: 742553]. The CD5 BV786 ASR development lots are on average 29% brighter based upon positive population MFI. Lysed whole blood gated on lymphocytes.
![CD16 BV786 Graph](/content/dam/bdb/campaigns/elevated/cd16-bv786-graph.jpg)
CD16 BV786 ASR (orange) compared to analogous CD16 BV786 RUO reagent (blue) [P/N: 563690]. Unstained sample in black. The CD16 BV786 ASR development lots are on average 11% brighter based upon positive population MFI. Lysed whole blood gated on granulocytes.
With an expanded portfolio of ASRs for violet laser channels, you will now have increased flexibility in multicolor panel design. This allows more options to move panel markers to the violet laser channels freeing up the blue and red laser channels.
Illustrative examples from product development are shown in Figures 7, 8 and 9.
![CD4 BV711 Graph](/content/dam/bdb/campaigns/elevated/cd4-bv711-2-graph.jpg)
CD4 BV711 ASR (orange) compared to CD4 PE ASR (blue) and CD4 PerCP-Cy5.5 ASR (pink). CD4 BV711 ASR development lot is equivalent in brightness to the CD19 PE ASR and 90% brighter than the PerCP-Cy5.5 ASR based upon positive population MFI. Clone: SK3. Lysed whole blood gated on lymphocytes.
![CD4 BV786 Graph](/content/dam/bdb/campaigns/elevated/cd4-bv786-graph.jpg)
CD4 BV786 (orange) compared to CD4 PE ASR (blue) and CD4 PerCP- Cy5.5 ASR (pink). CD4 BV786 ASR development lot is 37% and 94% brighter than CD4 PE ASR and CD4 PerCP- Cy5.5 ASR, respectively, based upon positive population MFI. Clone: SK3. Lysed whole blood gated on lymphocytes.
![CD14 BV711 Graph](/content/dam/bdb/campaigns/elevated/cd14-bv711-graph.jpg)
CD14 BV711 (orange) compared to CD14 PE (blue) and CD14 FITC (brown). CD14 BV711 ASR development lot is equivalent in brightness to the CD14 PE ASR and 39% brighter than the FITC ASR based on the positive population MFI. Unstained sample in black. Clone: MᶲP9. Lysed whole blood gated on monocytes.
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New ASRs
The following BD Horizon Brilliant™ ASRs are now available for consistency, brightness and channel flexibility.
Description | Clone | ASR Cat. No. | ASR with BD Horizon Brilliant Stain Buffer GPR Cat. No. |
---|---|---|---|
CD4 BV711 | SK3 | 664519 | 664539 |
CD10 BV711 | HI10a | 664520 | 664540 |
CD13 BV711 | L138 | 664521 | 664541 |
CD14 BV711 | MᶲP9 | 664522 | 664542 |
CD38 BV711 | HB7 | 664523 | 664543 |
CD56 BV711 | NCAM16.2 | 664524 | 664544 |
CD123 BV711 | 9F5 | 664525 | 664545 |
Mouse IgG1 BV711 | X40 | 664526 | 664546 |
CD3 BV786 | SK7 | 664527 | 664547 |
CD4 BV786 | SK3 | 664528 | 664548 |
CD5 BV786 | L17F12 | 664529 | 664549 |
CD8 BV786 | SK1 | 664530 | 664550 |
CD16 BV786 | 3G8 | 664531 | 664551 |
CD19 BV786 | SJ25C1 | 664532 | 664552 |
CD20 BV786 | L27 | 664533 | 664553 |
CD23 BV786 | EBVCS-5 | 664534 | 664554 |
CD45 BV786 | HI30 | 664535 | 664555 |
HLA-DR BV786 | G46-6 | 664536 | 664556 |
Mouse IgG1 BV786 | X40 | 664537 | 664557 |
Further expanding the ASR portfolio beyond BD Horizon Brilliant™ ASRs, the following ASRs are now also available to increase panel flexibility.
Description | Clone | ASR Cat. No. |
---|---|---|
CD22 PE-Cy7 | S-HCL-1 | 664538 |
Analyte Specific Reagent. Analytical and performance characteristics are not established.
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